Department of Medical Physiology, Texas A&M Health Science Center, College of Medicine, Bryan, TX 77807, USA.
Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, Bryan, TX 77807, USA.
Exp Biol Med (Maywood). 2020 Jul;245(13):1073-1086. doi: 10.1177/1535370220934038. Epub 2020 Jun 27.
Hypoxia contributes to tumor aggressiveness and promotes growth of many solid tumors that are often resistant to conventional therapies. In order to achieve successful therapeutic strategies targeting different cancer types, it is necessary to understand the molecular mechanisms and signaling pathways that are induced by hypoxia. Aberrant tumor vasculature and alterations in cellular metabolism and drug resistance due to hypoxia further confound this problem. This review focuses on the implications of hypoxia in an inflammatory TME and its impact on the signaling and metabolic pathways regulating growth and progression of cancer, along with changes in lymphangiogenic and angiogenic mechanisms. Finally, the overarching role of hypoxia in mediating therapeutic resistance in cancers is discussed.
缺氧会促进肿瘤的侵袭性，并促进许多实体瘤的生长，而这些肿瘤通常对传统疗法具有抗性。为了实现针对不同癌症类型的成功治疗策略，有必要了解由缺氧诱导的分子机制和信号通路。由于缺氧导致的异常肿瘤血管生成和细胞代谢及耐药性改变进一步使问题复杂化。本综述重点讨论了缺氧在炎症性肿瘤微环境中的意义及其对调节癌症生长和进展的信号和代谢途径的影响，以及淋巴管生成和血管生成机制的变化。最后，讨论了缺氧在介导癌症治疗抵抗中的总体作用。
