Clinical Sciences, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, Nicosia, Cyprus.
Otol Neurotol. 2010 Apr;31(3):528-35. doi: 10.1097/MAO.0b013e3181cdd6b7.
Neurogenic vestibular evoked potentials that are recorded from the scalp have so far been recorded in the form of N3 (click air-conducted), N5 (tone air-conducted), and P10 (bone-conducted stimulus) waveforms. The purpose of this study is to find other vestibular waveforms obtained with air-conducted sound.
The experiments were organized into 4 parts: 1) topographic scalp mapping; 2) determining the consistency in appearance of candidate vestibular waveforms; 3) further characteristics such as their relationship to vestibular evoked myogenic potentials, sensitivity to 5-kHz tone, and threshold of activation; and (D) recording of the new vestibular waveforms in a case of hearing loss.
A montage was discovered, O2-P3 and O1-P4 with left and right ear stimulation respectively, that yielded a negative wave at 6 milliseconds after stimulus onset and was labeled N6. It is not a vestibular evoked myogenic potential, disappears with 5-kHz tone stimuli, has a high threshold of stimulation, and is present in a case of hearing loss.
A new vestibular waveform is discovered that probably originates at or near the midbrain based on its latency. Together with the previously mentioned waves, lesions along the vestibular pathway can now be localized further.
迄今为止，从头皮记录的神经源性前庭诱发电位已以 N3（点击气导）、N5（音气导）和 P10（骨导刺激）波的形式记录。本研究的目的是寻找其他通过气导声音获得的前庭波形。
实验分为 4 部分：1）头皮地形图；2）确定候选前庭波形出现的一致性；3）进一步研究其与前庭诱发肌源性电位的关系、对 5kHz 音的敏感性和激活阈值等特征；4）记录听力损失患者的新前庭波形。
发现一种由左、右耳刺激产生的 O2-P3 和 O1-P4 导联，在刺激后 6 毫秒出现负波，标记为 N6。它不是前庭诱发肌源性电位，随着 5kHz 音刺激而消失，刺激阈值高，且在听力损失患者中存在。
根据潜伏期，我们发现了一种新的前庭波形，它可能起源于中脑或其附近。与之前提到的波一起，现在可以进一步定位前庭通路中的病变。
