Okayama H, Okayama M, Aikawa T, Sasaki M, Takishima T
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
J Asthma. 1991;28(1):11-7. doi: 10.3109/02770909109073366.
The bronchodilating effect of magnesium sulfate (MgSO4) was studied in two patients with status asthmaticus, who were intubated and mechanically ventilated by a respirator. Airway resistance was continuously monitored by the respiration-controlled interruption technique. After administration of 0.5 mmol/min MgSO4 intravenously, airway resistance decreased from 17 to 9, and from 13 to 8 mmHg/L/s in the two patients, respectively, and piping rales diminished or disappeared. We conclude that while corticosteroid therapy requires several hours to demonstrate significant effects in status asthmaticus, MgSO4 is of great benefit in the rapid improvement of airflow obstruction.
在两名哮喘持续状态患者中研究了硫酸镁（MgSO4）的支气管扩张作用，这两名患者均已插管并通过呼吸机进行机械通气。采用呼吸控制中断技术持续监测气道阻力。静脉内以0.5 mmol/分钟的速度给予MgSO4后，两名患者的气道阻力分别从17降至9以及从13降至8 mmHg/L/s，哮鸣音减弱或消失。我们得出结论，虽然皮质类固醇疗法在哮喘持续状态中需要数小时才能显示出显著效果，但MgSO4在迅速改善气流阻塞方面具有很大益处。
