Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India.
Mini Rev Med Chem. 2009 Dec;9(14):1639-47. doi: 10.2174/138955709791012292.
From the past few decades, tremendous awareness has been laid on the use of natural polymers in ocular drug delivery. Chitosan, a modified natural carbohydrate polymer, has number of applications in the field of ophthalmics and attracted a great deal of attention of scientific community, academicians and environmentalists due to its unique features. Chitosan has been explored for the delivery of drugs, genes, biotechnological products, proteins and peptides to the target site within ocular tissues. Chitosan being a polycationic in nature interacts with the polyanionic surface of ocular mucosa through hydrogen bonding /ionic interactions and enhance the mucoadhesive effect of formulation. Sustained and controlled ocular delivery can be achieved with chitosan based formulations like chitosan gels, inserts, chitosan coated liposome/niosome and chitosan nanoparticles. This review discussed various aspects related to chitosan and chitosan based formulations particularly developed for ocular therapeutics. The fate and toxicological consideration related to chitosan, resulting with its interaction to ocular tissues, has also been summed up in addition.
从过去几十年开始，人们对在眼部药物输送中使用天然聚合物的关注度大大提高。壳聚糖是一种经过修饰的天然碳水化合物聚合物，在眼科领域有多种应用，并因其独特的特性而引起科学界、学者和环保主义者的极大关注。壳聚糖已被探索用于将药物、基因、生物技术产品、蛋白质和肽递送至眼部组织内的靶位。壳聚糖具有聚阳离子性质，通过氢键/离子相互作用与眼部黏膜的聚阴离子表面相互作用，并增强制剂的粘膜粘附效果。基于壳聚糖的制剂，如壳聚糖凝胶、插入物、壳聚糖包被的脂质体/奈脂质体和壳聚糖纳米粒，可以实现持续和控制的眼部递药。本文综述了与壳聚糖及其专门为眼部治疗开发的基于壳聚糖的制剂相关的各个方面。此外，还总结了与壳聚糖相关的命运和毒理学考虑因素，以及其与眼部组织的相互作用。
