Farr Katherina Podlekareva, Mogensen Christian Backer
Onkologisk Afdeling D, Arhus Universitetshospital, Arhus Sygehus, DK-8000 Arhus, Denmark.
Ugeskr Laeger. 2010 Jan 25;172(4):298-9.
Drug-induced aseptic meningitis is a rare adverse effect of some drugs. We report a patient with four episodes of meningitis caused by ibuprofen. In all episodes the patient had taken ibuprofen for pain, and subsequently developed fever and cerebrovascular symptoms. Drug-induced meningitis cannot be distinguished from meningitis caused by other agents. Diagnosis is therefore based on close association between drug administration and onset of symptoms, as well as negative microbiology tests results, especially if previous episodes of drug-induced meningitis have occurred.
药物性无菌性脑膜炎是某些药物罕见的不良反应。我们报告一名因布洛芬导致四次脑膜炎发作的患者。在所有发作中,患者均服用布洛芬止痛,随后出现发热和脑血管症状。药物性脑膜炎无法与其他病原体引起的脑膜炎相区分。因此,诊断基于用药与症状发作之间的密切关联以及微生物学检测结果为阴性,尤其是既往有药物性脑膜炎发作史的情况。