Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.
Brain Res Bull. 2010 Apr 29;82(1-2):118-23. doi: 10.1016/j.brainresbull.2010.01.006. Epub 2010 Jan 25.
The consolidation of memories in a variety of learning processes benefits from post-training sleep, and recent work has suggested a role for sleep slow wave activity (SWA). Previous studies using a visuomotor learning task showed a local increase in sleep SWA in right parietal cortex, which was correlated with post-sleep performance enhancement. In these as in most similar studies, learning took place in the evening, shortly before sleep. Thus, it is currently unknown whether learning a task in the morning, followed by the usual daily activities, would also result in a local increase in sleep SWA during the night, and in a correlated enhancement in performance the next day. To answer this question, a group of subjects performed a visuomotor learning task in the morning and was retested the following morning. Whole night sleep was recorded with high-density EEG. We found an increase of SWA over the right posterior parietal areas that was most evident during the second sleep cycle. Performance improved significantly the following morning, and the improvement was positively correlated with the SWA increase in the second sleep cycle. These results suggest that training-induced changes in sleep SWA and post-sleep improvements do not depend upon the time interval between original training and sleep.
在各种学习过程中，记忆的巩固都得益于训练后的睡眠，而最近的研究表明睡眠慢波活动（SWA）发挥了作用。先前使用视觉运动学习任务的研究表明，右顶叶皮层的睡眠 SWA 局部增加，这与睡眠后表现的提高有关。在这些研究中，和大多数类似的研究一样，学习是在晚上，也就是睡觉前不久进行的。因此，目前尚不清楚如果在早上学习一项任务，然后进行日常活动，是否会导致夜间睡眠 SWA 局部增加，并在第二天的表现中相关地提高。为了回答这个问题，一组受试者在早上进行了视觉运动学习任务，并在第二天早上进行了重新测试。整晚的睡眠都用高密度 EEG 记录下来。我们发现，右侧后顶叶区域的 SWA 增加，在第二个睡眠周期最为明显。第二天早上的表现明显提高，而这种提高与第二个睡眠周期的 SWA 增加呈正相关。这些结果表明，睡眠 SWA 的训练诱导变化和睡眠后的改善并不取决于原始训练和睡眠之间的时间间隔。
