Department of Neurology, University of Ulm, Ulm, Germany.
J Neurol Sci. 2009 Dec;287 Suppl 1:S7-10. doi: 10.1016/S0022-510X(09)71294-8.
The onset of multiple sclerosis presents in 85% of cases as a subacute clinical event, the so-called clinically isolated syndrome. This event involves either focal or multifocal brain regions, most frequently the optic nerve, brainstem or spinal cord. The initial diagnosis of multiple sclerosis necessitates the demonstration of dissemination of pathology in time and space, as well as the exclusion of other alternative diagnoses, and can be challenging. Confirming a diagnosis of multiple sclerosis is a sensitive time for both patient and physician. The patient is faced with a difficult diagnosis and the physician must consider making difficult treatment decisions regarding therapy and follow-up care. This article presents a number of case studies that illustrate the diversity of presentation of clinically isolated syndrome and the challenges associated with confirming a diagnosis of multiple sclerosis.
多发性硬化症的发病在 85%的病例中表现为亚急性临床事件，即所谓的临床孤立综合征。这种事件涉及到局灶性或多灶性脑区，最常见的是视神经、脑干或脊髓。多发性硬化症的初始诊断需要证明病理学在时间和空间上的扩散，以及排除其他替代诊断，这可能具有挑战性。确认多发性硬化症的诊断对患者和医生来说都是一个敏感的时刻。患者面临着一个困难的诊断，医生必须考虑做出关于治疗和随访护理的困难治疗决策。本文介绍了一些病例研究，说明了临床孤立综合征的表现多样性，以及确认多发性硬化症诊断所面临的挑战。
