Das S R, Asiri S, el-Soofi A, Baer H P
Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
J Infect Dis. 1991 Apr;163(4):916-7. doi: 10.1093/infdis/163.4.916.
BALB/c mice inoculated nasally with Acanthamoeba culbertsoni, resulting in amebic encephalitis and death 3-7 days, were treated with rifampicin prophylactically (daily for 2 days with 75 and 100 mg/kg) and after infection (daily for 5 days with doses of 10-100 mg/kg). Prophylactic treatment resulted in full protection against infection, as assessed by absence of symptoms of central nervous system malfunction and negative brain culture 10 days after inoculation. Curative treatment was effective at the same doses; however, at doses of 10, 25, and 50 mg/kg, only two of six animals were free of symptoms and infection.
经鼻腔接种库氏棘阿米巴的BALB/c小鼠会在3至7天内引发阿米巴性脑炎并死亡，对这些小鼠进行了利福平预防性治疗（连续2天，剂量分别为75和100毫克/千克）以及感染后治疗（连续5天，剂量为10至100毫克/千克）。预防性治疗可提供完全的感染防护，接种10天后通过中枢神经系统功能障碍症状的缺失以及脑培养阴性来评估。相同剂量的治疗性治疗也是有效的；然而，在10、25和50毫克/千克的剂量下，六只动物中只有两只没有症状且未感染。
