Lespinasse P, Guard O, Yoa R, Noblet C, Rapin J R
Département de Pharmacie Clinique (INRPVC), UFR de Pharmacie, Dijon.
J Mal Vasc. 1991;16(1):43-5.
In a previous work we showed an alteration of erythrocyte filtration ability in patients with Alzheimer's disease according to their age and illness duration. This study has for aim to find a criteria of deformability that would be constant in all Alzheimer patients and would show a modification of red cell membranes. The erythrocyte filterability was studied in this present paper, in accord to Reid and Dormandy method using two values of depression (5 and 0 cm of water). These depressions correspond to the physiological values of blood pressure at the level of precapillary and capillary systems. The ratio between the result obtained at 5 cm and the result at 0 cm is constant in normal patient without organic disease and it is independent of age. At the opposite, this ratio increase very significantly in all Alzheimer patients, and this is not correlated to the initial value of filtrability. This ratio could be an index of the alteration of red cell membranes.
在之前的一项研究中，我们发现阿尔茨海默病患者的红细胞过滤能力会根据其年龄和病程发生改变。本研究旨在寻找一种在所有阿尔茨海默病患者中都恒定不变且能显示红细胞膜改变的可变形性标准。本文采用里德和多尔曼迪方法，通过两个负压值（5厘米水柱和0厘米水柱）对红细胞过滤性进行了研究。这些负压值分别对应于毛细血管前和毛细血管系统水平的血压生理值。在无器质性疾病的正常患者中，5厘米水柱时获得的结果与0厘米水柱时获得的结果之比是恒定的，且与年龄无关。相反，在所有阿尔茨海默病患者中，该比值显著增加，且与过滤性的初始值无关。这个比值可能是红细胞膜改变的一个指标。
