A new function for old drugs.
作者信息
Das Riku, Plow Edward F
出版信息
Cell Cycle. 2010 Feb 15;9(4):638-9. doi: 10.4161/cc.9.4.11016. Epub 2010 Feb 18.
Abstract
摘要
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A new function for old drugs.旧药新功能。
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L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages.L型钙通道阻滞剂通过抑制巨噬细胞上纤溶酶原受体的表达发挥抗炎作用。
Circ Res. 2009 Jul 17;105(2):167-75. doi: 10.1161/CIRCRESAHA.109.200311. Epub 2009 Jun 11.
2
Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung.烯醇化酶-1促进纤溶酶原介导的单核细胞向急性炎症肺组织的募集。
Blood. 2009 May 28;113(22):5588-98. doi: 10.1182/blood-2008-08-170837. Epub 2009 Jan 30.
3
Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.在小鼠中，炎性巨噬细胞迁移需要纤溶酶原激活基质金属蛋白酶-9。
J Clin Invest. 2008 Sep;118(9):3012-24. doi: 10.1172/JCI32750.
4
Histone H2B as a functionally important plasminogen receptor on macrophages.组蛋白H2B作为巨噬细胞上功能重要的纤溶酶原受体。
Blood. 2007 Nov 15;110(10):3763-72. doi: 10.1182/blood-2007-03-079392. Epub 2007 Aug 9.
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Plasminogen is an important regulator in the pathogenesis of a murine model of asthma.纤溶酶原是哮喘小鼠模型发病机制中的一个重要调节因子。
Am J Respir Crit Care Med. 2007 Aug 15;176(4):333-42. doi: 10.1164/rccm.200609-1345OC. Epub 2007 May 31.
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The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.纤溶酶原激活物/纤溶酶系统对于II型胶原诱导性关节炎关节炎症期的发展至关重要。
Am J Pathol. 2005 Mar;166(3):783-92. doi: 10.1016/S0002-9440(10)62299-7.
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