Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22, Showamachi, Maebashishi, Gunma 371-8511, Japan.
Acta Derm Venereol. 2010;90(1):73-6. doi: 10.2340/00015555-0758.
Cutaneous adverse effects of imatinib mesylate (Glivec) are common and various types of skin eruptions have been reported. We report here a 57-year-old man who presented with lichen planus-like lesions on his extremities and palmoplantar hyperkeratosis due to the use of imatinib mesylate for chronic myeloid leukaemia. The skin lesions improved after discontinuation of imatinib mesylate but re-administration of the drug at a lower dose provoked a mild recurrence. He could, however, continue to take the drug at the lower dose and his skin lesions were well-controlled by topical corticosteroid treatment. The literature on lichenoid drug eruption due to imatinib mesylate is reviewed.
甲磺酸伊马替尼（格列卫）的皮肤不良反应很常见，已有各种类型的皮肤疹报道。我们在此报告一例 57 岁男性患者，因慢性髓性白血病使用甲磺酸伊马替尼后出现肢端和掌跖过度角化及扁平苔藓样皮损。停用甲磺酸伊马替尼后皮肤病变改善，但再次以较低剂量使用该药时，轻度复发。然而，他可以继续以较低剂量服用该药，局部皮质类固醇治疗可很好地控制皮肤病变。我们还对甲磺酸伊马替尼引起的类扁平苔藓样药物疹的文献进行了复习。
