Jungquist G, Hanson B S, Isacsson S O, Janzon L, Steen B, Lindell S E
Department of Clinical Physiology, Lund University, Malmö General Hospital, Sweden.
J Clin Epidemiol. 1991;44(4-5):347-53. doi: 10.1016/0895-4356(91)90073-i.
Four hundred and seventy-eight men born in 1914 and residing in the city of Malmö, Sweden, underwent ultrasonic Doppler examination of the carotid arteries in 1982/83. The known risk factors for vascular disease--blood pressure, lipids, glucose, hematocrit, alcohol consumption and Body Mass Index were also measured. A moderate stenosis (diameter reduction 30-59%) of the internal carotid artery was found in 95 men (20%); 15 men (3%) had a greater than or equal to 60% stenosis of the internal carotid artery, while 7 (1.5%) had complete unilateral occlusion. Smoking was found to be significantly related to severe carotid artery disease. There was also a significant correlation between maximum flow velocity in the internal carotid artery and triglycerides. Those quitting smoking before the age of 50 had the same incidence of internal carotid artery disease as non-smokers, while those quitting later in life had a slightly higher incidence than life-long smokers.
1914年出生且居住在瑞典马尔默市的478名男性于1982年/1983年接受了颈动脉超声多普勒检查。同时还测量了已知的血管疾病危险因素——血压、血脂、血糖、血细胞比容、酒精摄入量和体重指数。95名男性(20%)发现颈内动脉有中度狭窄(直径缩小30 - 59%);15名男性(3%)颈内动脉狭窄大于或等于60%,而7名男性(1.5%)有单侧完全闭塞。发现吸烟与严重颈动脉疾病显著相关。颈内动脉最大流速与甘油三酯之间也存在显著相关性。50岁之前戒烟者的颈内动脉疾病发病率与不吸烟者相同,而在晚年戒烟者的发病率比终生吸烟者略高。