Applegate W B, Hughes J P, Vander Zwaag R
Department of Medicine, University of Tennessee, Memphis.
J Clin Epidemiol. 1991;44(4-5):409-15. doi: 10.1016/0895-4356(91)90079-o.
We undertook a case-control study utilizing a large coronary arteriography database to determine if traditional cardiovascular risk factors are as predictive of the presence of angiographically-proven coronary artery disease (CAD) in elderly patients as in younger patients. Among the patients aged 65 years or more, there were 2120 cases and 193 controls, while for the patients aged 35-49 years there were 1493 cases and 707 controls. Odds ratios obtained from logistic regression indicated that age, male sex, diabetes, cigarette smoking, hypertension, total cholesterol and left ventricular hypertrophy were all significant risk factors for CAD in both age groups, although the odds ratios tended to be somewhat lower in the elderly. Logistic regression analysis for gender subgroups generally revealed similar findings when compared with the combined (males + females) age groups, although power was limited for the subgroup of elderly males which had few controls. We conclude that most of the traditional cardiovascular risk factors which have been described as correlated with the presence of CAD in younger populations are also correlated with angiographically-proven CAD in older patients.
我们利用一个大型冠状动脉造影数据库进行了一项病例对照研究，以确定传统心血管危险因素对老年患者血管造影证实的冠状动脉疾病（CAD）的预测能力是否与年轻患者相同。在65岁及以上的患者中，有2120例病例和193例对照，而在35 - 49岁的患者中，有1493例病例和707例对照。逻辑回归得到的比值比表明，年龄、男性、糖尿病、吸烟、高血压、总胆固醇和左心室肥厚在两个年龄组中都是CAD的显著危险因素，尽管老年组的比值比往往略低。与合并（男性 + 女性）年龄组相比，性别亚组的逻辑回归分析通常显示出相似的结果，尽管老年男性亚组的检验效能有限，因为该亚组的对照较少。我们得出结论，大多数在年轻人群中被描述为与CAD存在相关的传统心血管危险因素，在老年患者中也与血管造影证实的CAD相关。
