Diskapi Educational and Research Hospital, Anesthesia Clinic, Kumeevler Cad. 2751/1 Sok. Siyasal Villari No: 44, Yenimahalle, Ankara, Turkey.
J Anesth. 2010 Apr;24(2):300-2. doi: 10.1007/s00540-010-0869-6. Epub 2010 Jan 28.
The objective of this study was to assess the effects of lidocaine on the incidence and severity of myoclonic movements induced by etomidate. Sixty patients were randomly assigned to receive either 20 mg lidocaine or saline (n = 30, each), 30 s before administration of etomidate (0.3 mg/kg). One minute after etomidate administration we assessed severity of myoclonus. Pretreatment with lidocaine significantly reduced both the incidence and severity of myoclonic movements. As a conclusion, lidocaine is an effective and safe drug to reduce the etomidate-induced myoclonus without significant side effects.
本研究旨在评估利多卡因对依托咪酯诱导肌阵挛发生和严重程度的影响。60 名患者随机分为利多卡因组（n=30）和生理盐水组（n=30），在给予依托咪酯（0.3mg/kg）前 30 秒分别给予 20mg 利多卡因或生理盐水。在给予依托咪酯后 1 分钟评估肌阵挛的严重程度。利多卡因预处理可显著降低肌阵挛的发生率和严重程度。总之，利多卡因是一种有效且安全的药物，可减少依托咪酯引起的肌阵挛，且无明显副作用。
