Department of Neurology, Royal Perth Hospital, Perth, Australia.
Mov Disord. 2010 Feb 15;25(3):397-401. doi: 10.1002/mds.22852.
Intramuscular injection of botulinum toxin (BoNT) produces reversible blockade of neuromuscular transmission. In animal experimental models, recovery begins within four weeks and is usually complete by twelve weeks. We present evidence of prolonged denervation following BoNT injection of the vastus lateralis (VL) muscle to correct quadriceps muscle imbalance in patients with chronic anterior knee pain. Needle electromyography data were obtained from 10 subjects who had received a single BoNT treatment 5 to 19 months earlier as part of a clinical trial. Insertional and spontaneous activity, recruitment, and motor unit action potentials were examined. Clear differences between the injected and non-injected VL muscles, which correlated with the time since injection, were identified in all subjects. All 10 subjects studied with needle EMG showed evidence of persisting denervation in the BoNT-A injected VL muscle beyond the period of neuromotor recovery expected from animal experimental studies.
肌肉内注射肉毒毒素（BoNT）可产生神经肌肉传递的可逆阻滞。在动物实验模型中，恢复开始于四周内，通常在十二周内完全恢复。我们提供了在慢性前膝痛患者中使用 BoNT 注射股外侧肌（VL）来纠正股四头肌失衡后神经支配持续丧失的证据。针电极肌电图数据来自 10 名受试者，他们在 5 至 19 个月前作为临床试验的一部分接受了单次 BoNT 治疗。插入和自发性活动、募集和运动单位动作电位都进行了检查。所有受试者的注射和未注射 VL 肌肉之间存在明显差异，这些差异与注射后的时间相关，在所有受试者中都得到了证实。所有接受针 EMG 研究的 10 名受试者均显示 BoNT-A 注射 VL 肌肉中的神经支配持续丧失的证据，这超出了动物实验研究中预期的神经运动恢复时间。
