具有嗜天青颗粒的骨髓瘤细胞——一种不寻常的形态学变异——病例报告。

Myeloma cells with asurophilic granules--an unusual morphological variant--case presentation.

作者信息

Vlădăreanu Ana Maria, Cîşleanu Diana, Derveşteanu Mihaela, Onisâi Minodora, Bumbea Horia, Radeşi Sînziana, Begu Mădălina, Cristina Băluţă

机构信息

University of Medicine and Pharmacy Carol Davila, Clinic of Hematology Universitary Emergency Hospital, Bucharest.

出版信息

J Med Life. 2008 Jan-Mar;1(1):74-86.

PMID:20108484

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3018960/

Abstract

We present the case of an 80-year-old man who was admitted for anemia, back pain and progressive weakness. After a workup of clinical and laboratory data, the final diagnosis was multiple myeloma. The bone marrow aspirate revealed 53% myeloma cells with peculiar and rare morphological features: numerous large asurophilic--bright red granules--mucopolizaccharides and immunoglobulins secreted and accumulated in the endoplasmic reticulum, typically known as Russel bodies.

摘要

我们报告一例80岁男性患者，因贫血、背痛和进行性虚弱入院。经过临床和实验室数据检查，最终诊断为多发性骨髓瘤。骨髓穿刺显示53%的骨髓瘤细胞具有独特且罕见的形态特征：大量嗜酸性大颗粒——鲜红色颗粒——粘多糖和免疫球蛋白在内质网中分泌并积聚，即典型的拉塞尔小体。