H1抗组胺药与驾驶
H1 antihistamines and driving.
作者信息
Popescu Florin Dan
机构信息
Allergology Department, University of Medicine and Pharmacy "Carol Davila" Bucharest, Romania.
出版信息
J Med Life. 2008 Jul-Sep;1(3):262-8.
Driving performances depend on cognitive, psychomotor and perception functions. The CNS adverse effects of some H1 antihistamines can alter the patient ability to drive. Data from studies using standardized objective cognitive and psychomotor tests (Choice Reaction Time, Critical Flicker Fusion. Digital Symbol Substitution Test), functional brain imaging (Positron Emission Tomography, functional Magnetic Resonance Imaging), neurophysiological studies (Multiple Sleep Latency Test, auditory and visual evoked potentials), experimental simulated driving (driving simulators) and real driving studies (the Highway Driving Test, with the evaluation of the Standard Deviation Lateral Position, and the Car Following Test, with the measurement of the Brake Reaction Time) must be discussed in order to classify a H1 antihistamine as a true non-sedating one.
驾驶表现取决于认知、心理运动和感知功能。一些H1抗组胺药的中枢神经系统不良反应可能会改变患者的驾驶能力。必须讨论使用标准化客观认知和心理运动测试（选择反应时间、临界闪烁融合、数字符号替换测试）、功能性脑成像（正电子发射断层扫描、功能性磁共振成像）、神经生理学研究（多次睡眠潜伏期测试、听觉和视觉诱发电位）、实验性模拟驾驶（驾驶模拟器）以及实际驾驶研究（公路驾驶测试，评估横向位置标准差，以及跟车测试，测量制动反应时间）所获得的数据，以便将一种H1抗组胺药归类为真正的非镇静性药物。
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