一些新型噻唑烷-2,4-二酮衍生物的合成及其抗菌活性

Synthesis and antimicrobial activity of some novel thiazolidine-2,4-dione derivatives.

作者信息

Menteşe Arzu, Ceylan-Unlüsoy Meltem, Bozdağ-Dündar Oya, Altanlar Nurten, Ertan Rahmiye

机构信息

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, Turkey.

出版信息

Arzneimittelforschung. 2009;59(12):659-65. doi: 10.1055/s-0031-1296456.

DOI:10.1055/s-0031-1296456

PMID:20108653

Abstract

In this study, a series of phenylethylsulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (VII a-f, VIII a-f) and 5-methyl-[1,2,4]triazolyl-sulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (IX a-f, X a-f) were synthesized and evaluated for their antibacterial and antifungal activities against S. aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), B. subtilis (ATCC 6633), E. coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used bacteria.

摘要

在本研究中，合成了一系列苯乙硫基-1,3-噻唑并噻唑烷-2,4-二酮衍生物（VII a-f，VIII a-f）和5-甲基-[1,2,4]三唑基硫基-1,3-噻唑并噻唑烷-2,4-二酮衍生物（IX a-f，X a-f），并评估了它们对金黄色葡萄球菌（ATCC 25923）、耐甲氧西林金黄色葡萄球菌（MRSA ATCC 43300）、枯草芽孢杆菌（ATCC 6633）、大肠杆菌（ATCC 23556）和白色念珠菌（ATCC10145）的抗菌和抗真菌活性。发现所有化合物对所用细菌均有活性。