一些新型噻唑基噻唑烷-2,4-二酮衍生物的合成与抗菌活性
Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives.
作者信息
Bozdağ-Dündar Oya, Ozgen Ozen, Menteşe Arzu, Altanlar Nurten, Atli Onur, Kendi Engin, Ertan Rahmiye
机构信息
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandoğan, Ankara, Turkey.
出版信息
Bioorg Med Chem. 2007 Sep 15;15(18):6012-7. doi: 10.1016/j.bmc.2007.06.049. Epub 2007 Jun 29.
In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives (Va-f and VIa-f) were synthesized and evaluated for their antibacterial and antifungal activities against Staphylococcus aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), methicillin resistant S. aureus (MRSA isolate), and Escherichia coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used microorganisms.
在本研究中，合成了一系列噻唑基噻唑烷 - 2,4 - 二酮衍生物（Va - f和VIa - f），并评估了它们对金黄色葡萄球菌（ATCC 25923）、耐甲氧西林金黄色葡萄球菌（MRSA ATCC 43300）、耐甲氧西林金黄色葡萄球菌（MRSA分离株）、大肠杆菌（ATCC 23556）和白色念珠菌（ATCC10145）的抗菌和抗真菌活性。发现所有化合物对所使用的微生物均具有活性。
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