Zheng Yu-Ming, Cain Yong-Lin, Cheng Ji-Ru, Li Jun, Mo Yong-Kun, Gao Jian-Quan, Dong Zhi-Rong, Zhong Qing-Yan
Central Laboratory, Wuzhou Red Cross Hospital, Guangxi 543002, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Aug;23(4):285-7.
This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC).
Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rta/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker.
The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined.
Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.
本研究旨在探讨爱泼斯坦-巴尔病毒（EBV）Rta/IgG在鼻咽癌（NPC）诊断中的临床价值。
采用酶联免疫吸附试验（ELISA）检测211例未经治疗的NPC患者、413名对照者（包括203例非NPC耳鼻喉科患者和210名健康志愿者）血清中抗Rta/IgG抗体的存在情况。应用受试者操作特征（ROC）曲线对该肿瘤标志物进行系统评价。
NPC组Rta/IgG的rA值中位数显著高于对照组（P<0.001）。ROC曲线下面积为0.933。确定最佳临界值时，该标志物的敏感性和特异性分别为90.5%和90.1%。
ELISA法检测的Rta/IgG是EBV的一个新靶点，可能是NPC诊断的重要标志物之一。
