Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
World J Biol Psychiatry. 2010 Mar;11(2):141-7. doi: 10.3109/15622970903449846.
Based on a brief systematic review suggesting dyslipidemia in posttraumatic stress disorder (PTSD), we studied, for the first time, levels of blood lipids in patients with a DSM-IV diagnosis of PTSD caused by myocardial infarction (MI).
Study participants were eight patients with full PTSD, eight patients with subsyndromal PTSD, and 31 patients with no PTSD who were diagnosed using the Clinician-Administered PTSD Scale (CAPS) interview after a mean of 32+/-8 months after MI. Levels of total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and high-density lipoprotein-cholesterol (HDL-C) were determined in plasma.
Patients with full PTSD had lower HDL-C than patients with subsyndromal PTSD (P = 0.044) and those with no PTSD (P = 0.014) controlling for sex, body mass index, and statin equivalent dosage. Moreover, HDL-C levels were inversely associated with PTSD total symptoms (r = -0.33, P = 0.027), re-experiencing symptoms (r = -0.32, P = 0.036), and avoidance symptoms (r = -0.34, P = 0.025). There were no significant associations of PTSD diagnostic status and symptomatology with the three other lipid measures.
Chronic PTSD caused by MI was associated with lower plasma levels of HDL-C. The finding concurs with the notion of dyslipidemia partially underlying the atherosclerotic risk in individuals with PTSD caused by different types of trauma.
基于一项简要的系统评价提示创伤后应激障碍（PTSD）存在血脂异常，我们首次研究了心肌梗死（MI）后 PTSD 患者的血脂水平。
研究参与者为 8 名符合 DSM-IV 诊断的 PTSD 患者（PTSD 组）、8 名亚临床 PTSD 患者和 31 名无 PTSD 患者。使用临床医生管理 PTSD 量表（CAPS）访谈对他们进行诊断，平均在 MI 后 32+/-8 个月进行。在血浆中测定总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL-C）水平。
PTSD 组的 HDL-C 低于亚临床 PTSD 组（P=0.044）和无 PTSD 组（P=0.014），控制性别、体重指数和他汀类等效剂量。此外，HDL-C 水平与 PTSD 总症状（r=-0.33，P=0.027）、再体验症状（r=-0.32，P=0.036）和回避症状（r=-0.34，P=0.025）呈负相关。PTSD 诊断状态和症状与其他三种血脂指标无显著相关性。
MI 引起的慢性 PTSD 与血浆 HDL-C 水平降低有关。这一发现与不同类型创伤引起的 PTSD 个体存在血脂异常部分导致动脉粥样硬化风险的观点一致。
