患有与战斗相关的慢性创伤后应激障碍的退伍军人血清脂质升高。

Elevated serum lipids in veterans with combat-related chronic posttraumatic stress disorder.

作者信息

Solter Vlasta, Thaller Vlatko, Karlović Dalibor, Crnković Danijel

机构信息

University Department of Psychiatry, Sisters of Mercy University Hospital, Zagreb, Croatia.

出版信息

Croat Med J. 2002 Dec;43(6):685-9.

PMID:12476477

Abstract

AIM

To assess possible differences in serum cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, arteriosclerosis index, established risk factor (ERF) of arteriosclerosis, and 10-year risk for coronary disease according to the Adult Treatment Panel III (ATP-III) between veterans with combat-related posttraumatic stress disorder (PTSD) and a control group consisting of patients with major depressive disorder.

METHOD

We determined serum cholesterol, LDL-C, HDL-C, and triglycerides in the patients with PTSD (n = 103) and patients with major depressive disorder (n = 92), using the enzyme-assay method. AI, ERF, and ATP-III were calculated from cholesterol, LDL-C, and HDL-C levels. The groups were matched in age and body mass index (BMI). Patients with major depressive disorder were chosen as a control group because they do not have changes in serum lipids.

RESULTS

Patients with combat-related PTSD had higher mean concentration of cholesterol (6.2+/-1.1 mmol/L vs 5.3+/-0.9 mmol/L; p<0.001), LDL-C (3.9+/-0.7 mmol/L vs 3.5+/-1.0 mmol/L; p = 0.005), and triglycerides (2.9+/-2.3 mmol/L vs 1.5+/-0.5 mmol/L; p<0.001), and lower HDL-C (1.0+/-0.3 mmol/L vs 1.3+/-0.2 mmol/L; p<0.001) than the control group. Arteriosclerosis index (4.2+/-1.2 vs 3.7+/-1.7; p = 0.050), ERF (6.4+/-1.9 vs 5.5+/-2.4; p = 0.010), and ATP-III (12.1+/-3.3 vs 10.2+/-3.8; p<0.001) were higher in PTSD than in the control group.

CONCLUSION

Elevated concentrations of serum lipids are associated with combat-related PTSD. This may imply that patients with combat-related PTSD are under a higher risk for arteriosclerosis.

摘要

目的

根据成人治疗小组第三次报告（ATP-III），评估与战斗相关的创伤后应激障碍（PTSD）退伍军人与由重度抑郁症患者组成的对照组在血清胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯、动脉硬化指数、已确定的动脉硬化危险因素（ERF）以及冠心病10年风险方面可能存在的差异。

方法

我们采用酶法测定了103例PTSD患者和92例重度抑郁症患者的血清胆固醇、LDL-C、HDL-C和甘油三酯。根据胆固醇、LDL-C和HDL-C水平计算动脉硬化指数（AI）、ERF和ATP-III。两组在年龄和体重指数（BMI）方面进行了匹配。选择重度抑郁症患者作为对照组，因为他们的血脂没有变化。

结果

与战斗相关的PTSD患者的胆固醇平均浓度（6.2±1.1 mmol/L对 5.3±0.9 mmol/L；p<0.001）、LDL-C（3.9±0.7 mmol/L对 3.5±1.0 mmol/L；p = 0.005）和甘油三酯（2.9±2.3 mmol/L对 1.5±0.5 mmol/L；p<0.001）高于对照组，而HDL-C（1.0±0.3 mmol/L对 1.3±0.2 mmol/L；p<0.001）低于对照组。PTSD患者的动脉硬化指数（4.2±1.2对 3.7±1.7；p = 0.050）、ERF（6.4±1.9对 5.5±2.4；p = 0.010）和ATP-III（12.1±3.3对 10.2±3.8；p<0.001）高于对照组。