The Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Sichuan, China.
Am J Rhinol Allergy. 2010 Jan-Feb;24(1):e41-5. doi: 10.2500/ajra.2010.24.3430.
Because chronic rhinosinusitis (CRS) is one of the most common health conditions in humans, it is important to assess its impact on quality of life (QoL). This study investigated the relationship between the findings of computed tomography (CT) staging and a patient-based questionnaire for CRS patients in Western China.
In this prospective study, the Lund-MacKay CT staging system, a visual analog scale (VAS), the 20-Item Sinonasal Outcome Test (SNOT-20), and the Short Form 36 Health Survey (SF-36) were completed for all preoperative recruits. The patients were classified into several subgroups according to whether CRS was associated with nasal polyps (CRS with nasal polyps [CRSwNPs]) or not (CRS without nasal polyps [CRSsNPs]), sex, duration of disease, and educational background.
A total of 121 patients were recruited. In the total cohort of patients, there were significant correlations between scores on SNOT-20 and SF-36 (r = -0.561; p < 0.01), SNOT-20 and VAS (r = 0.743; p < 0.01), and SF-36 and VAS (r = -0.504; p < 0.01). Significant but weak correlations were found between the CT stage and scores on the patient-based questionnaires in the CRSwNP subgroup (CT versus SNOT-20, r = 0.31 and, p = 0.005; CT versus SF-36, r = -0.358 and p = 0.002; CT versus VAS, r = 0.358 and p = 0.002). The CT stage did not correlate with the scores in the patient-based questionnaires in the total cohort of patients. However, the CT stage was higher in the CRSwNP subgroup than in the CRSsNP, but QoL was better in the CRSwNP subgroup than in the CRSsNP subgroup. The two groups differed on the Lund-MacKay stage and the SNOT-20 and VAS scores (p < 0.05).
The scores on patient-based questionnaires such as the SNOT-20, SF-36, and VAS correlate with each other. The CT stage correlated weakly but significantly with the scores in the patient-based questionnaires only in the CRSwNP subgroup. The presence of nasal polyps was not associated with poor QoL in CRS patients.
慢性鼻-鼻窦炎（CRS）是人类最常见的健康问题之一，因此评估其对生活质量（QoL）的影响非常重要。本研究旨在探讨在中国西部，CT 分期与基于患者问卷的 CRS 患者评估之间的关系。
本前瞻性研究采用 Lund-MacKay CT 分期系统、视觉模拟评分（VAS）、20 项鼻-鼻窦结局测试（SNOT-20）和健康调查简表 36 项（SF-36）对所有术前入组患者进行评估。根据 CRS 是否伴有鼻息肉（CRSwNP）或不伴有鼻息肉（CRSsNP）、性别、病程和教育背景，将患者分为不同亚组。
共纳入 121 例患者。在总患者队列中，SNOT-20 和 SF-36 评分之间（r = -0.561；p < 0.01）、SNOT-20 和 VAS 评分之间（r = 0.743；p < 0.01）以及 SF-36 和 VAS 评分之间（r = -0.504；p < 0.01）均存在显著相关性。在 CRSwNP 亚组中，CT 分期与基于患者问卷的评分之间存在显著但较弱的相关性（CT 与 SNOT-20，r = 0.31，p = 0.005；CT 与 SF-36，r = -0.358，p = 0.002；CT 与 VAS，r = -0.358，p = 0.002）。但在总患者队列中，CT 分期与基于患者问卷的评分无相关性。然而，CRSwNP 亚组的 CT 分期高于 CRSsNP 亚组，但 CRSwNP 亚组的 QoL 好于 CRSsNP 亚组。两组在 Lund-MacKay 分期、SNOT-20 和 VAS 评分上存在差异（p < 0.05）。
SNOT-20、SF-36 和 VAS 等基于患者问卷的评分之间存在相关性。CT 分期仅在 CRSwNP 亚组中与基于患者问卷的评分存在弱但显著的相关性。鼻息肉的存在与 CRS 患者的生活质量差无关。
