Sánchez Yus E, Herrera M, Simón R S, Requena L
Departamento de Medicina II Dermatología, Facultad de Medicina, Universidad Complutense, Madrid, España.
Actas Dermosifiliogr. 2010 Jan-Feb;101(1):19-30.
For the past 40 years, the Clark classification of cutaneous melanoma has been accepted and used by the vast majority of dermatologists and pathologists throughout the world. However,after careful rereading of the most relevant articles by Clark and his collaborators, we can affirm that the classification was only ever of passing validity. Today, the possible morphological differences between one case of cutaneous melanoma and another are of no proven prognostic implication. In addition, the morphological differences that can be found are much more closely related to the different localization that to the tumor itself.
在过去40年里,皮肤黑色素瘤的克拉克分类法已被全球绝大多数皮肤科医生和病理学家接受并使用。然而,在仔细重读克拉克及其合作者的最相关文章后,我们可以肯定地说,该分类法仅具有短暂的有效性。如今,一例皮肤黑色素瘤与另一例之间可能存在的形态学差异并无已证实的预后意义。此外,所发现的形态学差异与肿瘤本身相比,与不同的定位关系更为密切。