Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.
Neuroscience. 2010 Apr 28;167(1):104-10. doi: 10.1016/j.neuroscience.2010.01.034. Epub 2010 Jan 28.
Age-dependent decrease in dopamine receptor density throughout adulthood is well described, meanwhile less is known about development of dopamine system in humans and in vivo it has not been investigated. We examined dopamine D1 receptor (D1DR) binding in the cerebral cortex and striatum of 12 adolescents (mean age 13.5+/-1.8 years) and 18 young adults (25+/-2.3 years) using positron emission tomography (PET) and radioligand [(11)C]SCH23390. Over the age span of 10-30 years [(11)C]SCH23390 binding (binding potential, BP) declined in all brain regions. The rate of BP decline was age-segment and brain region dependent. Most pronounced decline in BP was observed in the cortical regions during adolescence (mean BP in adults lower by 14-26% as compared to adolescents, P<0.0001). Significantly slower rate of decline in BP was observed in two cortical regions (orbitofrontal and posterior cingulate cortices) and striatal regions. The present PET-study provides new evidence on the development of D1DR in humans in vivo which is of critical importance for understanding of the biology of neurodevelopmental disorders.
整个成年期多巴胺受体密度随年龄的依赖性下降得到了很好的描述，而对于人类多巴胺系统的发育知之甚少，并且在体内尚未进行研究。我们使用正电子发射断层扫描（PET）和放射性配体[11C]SCH23390 检查了 12 名青少年（平均年龄 13.5±1.8 岁）和 18 名年轻人（25±2.3 岁）大脑皮层和纹状体中的多巴胺 D1 受体（D1DR）结合。在 10-30 岁的年龄范围内，[11C]SCH23390 结合（结合潜力，BP）在所有脑区均下降。BP 下降的速度与年龄段和脑区有关。在青春期，BP 的下降最为明显（与青少年相比，成年人的平均 BP 下降 14-26%，P<0.0001）。在两个皮层区域（眶额皮层和后扣带皮层）和纹状体区域观察到 BP 下降速度明显较慢。这项 PET 研究为理解神经发育障碍的生物学提供了人类体内 D1DR 发育的新证据，这对于理解神经发育障碍的生物学至关重要。
