Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
J Allergy Clin Immunol. 2010 Jan;125(1):217-21. doi: 10.1016/j.jaci.2009.10.045.
We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions.
To determine the relationship between atopic conditions other than asthma and SPD.
The study subjects were residents of Rochester, Minn, who developed SPD between 1964 and 1983 and their 2 sex-matched and age-matched controls. We used a population-based computer-linked medical diagnosis system to identify all individuals with potential SPD. All records were reviewed by using explicit predetermined criteria for SPD. All individuals with atopic conditions were identified by the physician diagnoses including atopic dermatitis or eczema, allergic rhinitis, and hay fever documented in medical records. The associations between these atopic conditions and SPD were assessed by using conditional logistic regression.
A total of 3941 records were reviewed, and we identified 174 SPD cases. Of these 174 cases, 50.6% were male, and 94.3% were Caucasian. Twenty-six (14.9%) of the SPD cases and 29 (8.3%) of the controls had atopy. Atopic conditions other than asthma were associated with an increased risk of SPD (odds ratio, 2.13; 95% CI, 1.04-4.35; P = .04) after adjusting for smoking status, previous high-risk conditions for SPD, educational status, and ethnicity.
Like asthma, other atopic conditions, particularly atopic dermatitis, are associated with an increased risk of SPD. There may be a common immunogenetic mechanism underlying increased risk of SPD among individuals with either asthma or other atopic conditions. Our study findings need to be studied further.
我们曾报告过哮喘患者罹患严重肺炎球菌病（SPD）的风险增加。但尚不清楚这一情况是否适用于患有其他特应性疾病的患者。
确定除哮喘以外的其他特应性疾病与 SPD 之间的关系。
研究对象为明尼苏达州罗彻斯特市的居民，他们在 1964 年至 1983 年间罹患 SPD，以及他们的 2 名性别和年龄匹配的对照者。我们使用基于人群的计算机关联医疗诊断系统来识别所有潜在的 SPD 患者。所有记录均通过使用明确的 SPD 预先确定标准进行了审查。所有患有特应性疾病的个体均通过医生诊断来确定，包括病历中记录的特应性皮炎或湿疹、变应性鼻炎和花粉热。通过条件逻辑回归评估这些特应性疾病与 SPD 之间的关联。
共审查了 3941 份记录，我们确定了 174 例 SPD 病例。在这 174 例病例中，50.6%为男性，94.3%为白种人。26 例（14.9%）SPD 病例和 29 例（8.3%）对照者患有特应性疾病。在调整吸烟状况、先前 SPD 的高危状况、教育程度和种族后，除哮喘以外的特应性疾病与 SPD 的风险增加相关（比值比，2.13；95%CI，1.04-4.35；P=0.04）。
与哮喘一样，其他特应性疾病，特别是特应性皮炎，与 SPD 的风险增加相关。在患有哮喘或其他特应性疾病的个体中，SPD 风险增加可能存在共同的免疫遗传机制。我们的研究结果需要进一步研究。
