哮喘对重症肺炎球菌疾病严重程度的影响。
Impact of Asthma on the Severity of Serious Pneumococcal Disease.
作者信息
Dhillon Ravneet K, Yawn Barbara P, Yoo Kwang Ha, Boyce Thomas G, Jacobson Robert M, McGree Michaela E, Weaver Amy L, Juhn Young J
机构信息
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Department of Research, Olmsted Medical Center, Rochester, MN.
出版信息
Epidemiology (Sunnyvale). 2011 Dec 25;Suppl 3. doi: 10.4172/2161-1165.S3-001.
We recently reported an increased risk of serious pneumococcal disease (SPD) in asthmatics. Little is known about the impact of asthma status on the severity of SPD. We compared the severity of serious pneumococcal disease (SPD) between patients with asthma and those without asthma. The study subjects were Rochester, Minnesota residents who developed SPD between 1964 and 1983. SPD and asthma status were ascertained by using explicit predetermined criteria Severity of SPD was assessed using intensive care unit (ICU) admission rate and total days of ICU stay and hospitalization associated with treatment for SPD. We found that there were no significant differences in severity outcomes between asthmatics (n=11) and non-asthmatics (n=163). Asthma status may increase the risk of SPD but not influence its severity. However, given a small sample size of our study, a larger study needs to be considered to clarify the relationship between asthma and severity of SPD.
我们最近报告称，哮喘患者患严重肺炎球菌疾病（SPD）的风险增加。关于哮喘状态对SPD严重程度的影响，人们了解甚少。我们比较了哮喘患者和非哮喘患者之间严重肺炎球菌疾病（SPD）的严重程度。研究对象是1964年至1983年间在明尼苏达州罗切斯特市患SPD的居民。通过使用明确的预定标准确定SPD和哮喘状态。使用重症监护病房（ICU）入院率、ICU住院总天数以及与SPD治疗相关的住院总天数来评估SPD的严重程度。我们发现，哮喘患者（n = 11）和非哮喘患者（n = 163）在严重程度结果方面没有显著差异。哮喘状态可能会增加患SPD的风险，但不会影响其严重程度。然而，鉴于我们研究的样本量较小，需要考虑进行更大规模的研究以阐明哮喘与SPD严重程度之间的关系。
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