Dereure O
Service de dermatologie, Hôpital Saint-Eloi, Montpellier, France.
Ann Dermatol Venereol. 2009 Dec;136 Suppl 7:S407-16. doi: 10.1016/S0151-9638(09)73382-4.
Fundamental research in Dermatology has been once more very active during the past year and more specifically focused on immunological grounds of inflammatory diseases, the identification of risk loci associated with psoriasis and tumors, cutaneous lymphomas and on the genodermatosis where large international collaborative studies provided with a molecular understanding of an increasing amount of conditions especially affecting pigmentation and differentiation. In silico investigations become increasingly prominent especially with the rising power of new actor, China, the demographical and resulting epidemiological weight of which can hardly be challenged. Some of these fundamental breakthroughs might result in practical interventions although in an undefined future.
在过去一年里,皮肤病学的基础研究再度十分活跃,尤其聚焦于炎症性疾病的免疫学基础、与银屑病和肿瘤、皮肤淋巴瘤相关的风险位点的识别,以及遗传性皮肤病。大型国际合作研究对越来越多的疾病,尤其是影响色素沉着和分化的疾病,提供了分子层面的理解。计算机模拟研究变得越来越突出,特别是随着新的重要力量——中国的崛起,其人口规模以及由此产生的流行病学影响力几乎无可匹敌。尽管在不确定的未来,这些基础研究突破中的一些可能会带来实际的干预措施。