Ayhan A, Yarali H, Ayhan A
Department of Obstetrics and Gynecology, University of Hacettepe, Faculty of Medicine, Ankara, Turkey.
J Surg Oncol. 1991 Mar;46(3):182-4. doi: 10.1002/jso.2930460312.
The association of some cases of endometrial carcinoma (EC) with hyperestrogenism is well known. The prognostic significance of concomitant endometrial hyperplasia (EH) in EC were evaluated in 142 patients with clinical stage I EC in whom lymph node assessment was carried out in 121 patients. The presence of EH was significantly associated with better differentiated tumor having lesser degrees of myometrial invasion, low segment-adnexal-lymphovascular space and pelvic/para-aortic lymph node involvement. However, the presence of EH was not significantly associated with the less virulent histologic subtypes. The possible existence of two types of EC--a hormonal-dependent EC associated with EH, and an independent EC not associated with EH--is discussed and the prognostic significance of concomitant EH stressed.
某些子宫内膜癌（EC）病例与雌激素过多症的关联已广为人知。对142例临床I期EC患者进行了评估，其中121例患者进行了淋巴结评估，以探讨EC中伴随的子宫内膜增生（EH）的预后意义。EH的存在与肿瘤分化较好、肌层浸润程度较轻、低段附件区淋巴管间隙以及盆腔/腹主动脉旁淋巴结受累显著相关。然而，EH的存在与恶性程度较低的组织学亚型无显著关联。文中讨论了可能存在两种类型的EC，即与EH相关的激素依赖性EC和与EH无关的独立性EC，并强调了伴随EH的预后意义。
