Mental Health Research Institute, University of Melbourne, Melbourne, VIC, Australia.
J Alzheimers Dis. 2010;19(2):423-8. doi: 10.3233/JAD-2010-1241.
Brain amyloid imaging is becoming an essential tool for the pre-mortem evaluation of Alzheimer's disease (AD). This study explores the pattern of 11C-PiB retention in a subject with Worster-Drought syndrome (WDS). A 55 year-old male carrier of the WDS gene mutation with mild signs of ataxia and subtle cognitive impairment underwent MRI and 11C-PiB-PET studies.Brain PiB regional distribution was compared to those from cohorts of healthy controls and AD patients. While no significant cortical 11C-PiB retention was present, a high degree of cerebellar 11C-PiB retention was observed in a genetically confirmed carrier of the WDS gene. We speculate that the sparsity of ABri plaques in the neocortex together with its high deposition in the cerebellum, might explain the observed pattern of 11C-PiB retention.
脑淀粉样蛋白成像正成为生前评估阿尔茨海默病（AD）的重要工具。本研究探讨了沃斯特-德劳特综合征（WDS）患者中 11C-PiB 保留的模式。一位 55 岁的男性是 WDS 基因突变的携带者，有轻微的共济失调和细微的认知障碍，他接受了 MRI 和 11C-PiB-PET 研究。将脑 PiB 区域分布与健康对照者和 AD 患者的队列进行比较。虽然没有明显的皮质 11C-PiB 保留，但在 WDS 基因突变的基因确证携带者中观察到高度的小脑 11C-PiB 保留。我们推测，新皮层中 ABri 斑块的稀疏性与其在小脑中的高沉积可能解释了观察到的 11C-PiB 保留模式。
