Reaven G M, Ho H
Department of Medicine, Stanford University School of Medicine, Palo Alto, CA.
Metabolism. 1991 Apr;40(4):335-7. doi: 10.1016/0026-0495(91)90141-i.
Streptozotocin (STZ, 35 mg/kg body weight) was injected into spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, and plasma glucose and triglyceride concentrations measured 10 days later. Neither mean (+/- SEM) plasma glucose (130 +/- 3 v 136 +/- 3 mg/dL) nor triglyceride (93 +/- 6 v 108 +/- 7 mg/dL) concentrations increased in WKY rats. In contrast, both plasma glucose (141 +/- 3 v 262 +/- 36) and triglyceride (121 +/- 8 v 196 +/- 7 mg/dL) concentrations increased significantly (P less than .01) following administration of STZ in SHR. Furthermore, when SHR previously injected with STZ were fed a diet enriched in fructose, they had a further increase (P less than .01) in both plasma glucose (343 +/- 38 mg/dL) and triglyceride (774 +/- 57 mg/dL) concentrations. Plasma triglyceride concentration also increased significantly (P less than .05) when STZ-injected WKY rats ingested the fructose-enriched diet, but plasma glucose levels still remained within the normal range (152 +/- 5 mg/dL). These results indicate that SHR were more sensitive to the effects of a decrease in pancreatic beta-cell function (STZ) and an increase in insulin resistance (fructose feeding) than WKY rats.
将链脲佐菌素（STZ，35毫克/千克体重）注射到自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠体内，10天后测量血浆葡萄糖和甘油三酯浓度。WKY大鼠的平均（±SEM）血浆葡萄糖（130±3对136±3毫克/分升）和甘油三酯（93±6对108±7毫克/分升）浓度均未升高。相比之下，给SHR注射STZ后，血浆葡萄糖（141±3对262±36）和甘油三酯（121±8对196±7毫克/分升）浓度均显著升高（P<0.01）。此外，先前注射过STZ的SHR喂食富含果糖的饮食后，血浆葡萄糖（343±38毫克/分升）和甘油三酯（774±57毫克/分升）浓度进一步升高（P<0.01）。注射STZ的WKY大鼠摄入富含果糖的饮食后，血浆甘油三酯浓度也显著升高（P<0.05），但血浆葡萄糖水平仍保持在正常范围内（152±5毫克/分升）。这些结果表明，与WKY大鼠相比，SHR对胰腺β细胞功能降低（STZ）和胰岛素抵抗增加（喂食果糖）的影响更敏感。
