Hulman S, Falkner B, Chen Y Q
Department of Pediatrics, Medical College of Pennsylvania, Philadelphia 19129.
Metabolism. 1991 Apr;40(4):359-61. doi: 10.1016/0026-0495(91)90145-m.
To determine experimentally if insulin resistance is associated with spontaneously occurring hypertension, insulin-stimulated glucose metabolism was studied in an animal model of genetic hypertension. The spontaneously hypertensive rat (SHR) and its genetic control, the Wistar-Kyoto strain (WKY) were studied with the euglycemic hyperinsulinemic clamp technique. Clamp studies demonstrated reduced insulin-stimulated glucose uptake in SHR (P less than .001). These data indicate that SHR is insulin-resistant when compared with WKY. A reduction of insulin-stimulated glucose metabolism occurred in older animals of both strains, providing evidence of an aging effect on insulin-stimulated glucose metabolism. However, the reduction of insulin-stimulated glucose metabolism was more pronounced in the hypertensive animals. This study demonstrates the presence of peripheral (skeletal muscle) insulin resistance in the SHR.
为了通过实验确定胰岛素抵抗是否与自发性高血压相关，在遗传性高血压动物模型中研究了胰岛素刺激的葡萄糖代谢。采用正常血糖高胰岛素钳夹技术对自发性高血压大鼠（SHR）及其遗传对照Wistar-Kyoto品系（WKY）进行了研究。钳夹研究表明，SHR中胰岛素刺激的葡萄糖摄取减少（P<0.001）。这些数据表明，与WKY相比，SHR存在胰岛素抵抗。两种品系的老年动物中胰岛素刺激的葡萄糖代谢均降低，这为衰老对胰岛素刺激的葡萄糖代谢的影响提供了证据。然而，高血压动物中胰岛素刺激的葡萄糖代谢降低更为明显。本研究证明了SHR中存在外周（骨骼肌）胰岛素抵抗。
