Salmela Michael B, Cauley Keith A, Andrews Trevor, Gonyea Jay V, Tarasiewicz Izabela, Filippi Christopher G
Department of Radiology, University of Vermont College of Medicine-Fletcher Allen Health Care, Burlington, VY 05401, USA.
Pediatr Neurosurg. 2009;45(6):467-71. doi: 10.1159/000262442. Epub 2010 Jan 26.
BACKGROUND/AIMS: As a preoperative planning tool, conventional magnetic resonance (MR) imaging may have limited value in differentiating tumors from white matter tracts. MR diffusion tensor imaging (MRDTI) has become a useful tool for evaluating white matter tracts in relation to surrounding structures and has been used in surgical planning for brain tumors involving white matter. We investigated the use of DTI of the optic nerves in surgical planning for pediatric suprasellar tumors.
We present findings in 10 pediatric control patients and 2 cases of pediatric suprasellar tumors in which a routine 6-direction DTI of the brain was performed at 3 T. Postprocessing permitted the study of the diffusion tensor parameters, as well as the tractography, of the optic nerves.
The control patients demonstrated the optimization of the technique and permitted the quantitation of fractional anisotropy and apparent diffusion coefficient values. The tumor cases demonstrated the utility of optic nerve DTI to differentiate between optic nerves and suprasellar/chiasmatic brain tumors.
A routine 6-direction DTI of the pediatric brain at 3 T permits a detailed DTI study of the optic nerves. Optic nerve tractography can be used to aid in the evaluation and treatment of pediatric brain tumors in the area of the optic chiasm.
背景/目的：作为一种术前规划工具，传统磁共振（MR）成像在区分肿瘤与白质束方面的价值可能有限。MR扩散张量成像（MRDTI）已成为评估白质束与周围结构关系的有用工具，并已用于涉及白质的脑肿瘤手术规划。我们研究了视神经扩散张量成像在儿童鞍上肿瘤手术规划中的应用。
我们展示了10例儿科对照患者和2例儿科鞍上肿瘤患者的研究结果，这些患者在3T条件下进行了常规的脑部六向扩散张量成像。后处理允许对视神经的扩散张量参数以及纤维束成像进行研究。
对照患者展示了该技术的优化，并允许对视神经各向异性分数和表观扩散系数值进行定量分析。肿瘤病例展示了视神经扩散张量成像在区分视神经与鞍上/视交叉脑肿瘤方面的实用性。
在3T条件下对儿科脑部进行常规的六向扩散张量成像可对视神经进行详细的扩散张量成像研究。视神经纤维束成像可用于辅助评估和治疗视交叉区域的儿科脑肿瘤。
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