Department of Radiology, Fletcher Allen Healthcare/University of Vermont, Burlington, Vermont, USA.
J Magn Reson Imaging. 2010 Jul;32(1):76-81. doi: 10.1002/jmri.22228.
To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway.
A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the optic nerves or exerting mass effect on the anterior optic pathways was performed. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained within the posterior part of the intraorbital optic nerves. Statistical analysis compared normal controls to optic pathway lesions.
Lesions intrinsic to the optic nerve including septo-optic dysplasia and optic nerve glioma demonstrated statistically significant reductions in FA and increases in ADC values. There was no statistically significant difference in FA or mean diffusivity between the normal controls and patients with lesions extrinsic to the optic nerve but exerting mass effect on the visual pathway.
MRDTI is a feasible technique for evaluating the optic nerves in pediatric patients. It may play a role in presurgical planning by demonstrating integrity of the visual pathway in patients with resectable lesions, allowing for minimization of morbidity associated with vision loss.
建立儿童视神经磁共振扩散张量成像(MRDTI)的规范数据,并将其与视神经前路径的内在和外在病理状况进行比较。
对 3.0T 磁共振 DT 成像的儿童(0-18 岁)进行回顾性分析,这些儿童既有正常影像学研究,也有源自视神经或对视神经前路径产生肿块效应的病理状况。在眶内视神经的后部分获得各向异性分数(FA)和表观扩散系数(ADC)值。统计分析将正常对照组与视路病变进行比较。
视神经内的病变,包括隔-视神经发育不良和视神经胶质瘤,FA 值显著降低,ADC 值显著升高。视神经外的病变对视路产生肿块效应,但与正常对照组相比,FA 值或平均弥散系数无统计学差异。
MRDTI 是一种评估儿科患者视神经的可行技术。它可以通过显示可切除病变患者视路的完整性来发挥作用,从而最大限度地减少与视力丧失相关的发病率。