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具有促凋亡潜力的化合物的合成及体外细胞毒性活性。

Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential.

机构信息

Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.

出版信息

Molecules. 2009 Dec 24;15(1):12-26. doi: 10.3390/molecules15010012.

DOI:10.3390/molecules15010012
PMID:20110868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6256932/
Abstract

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.

摘要

在寻找新的抗癌疗法的过程中，我们选择了实验室合成的一些化合物，并在体外评估了它们对两种癌细胞系（包括一种实体瘤[UACC-62，黑色素瘤]和一种人淋巴瘤[JURKAT]）的潜在细胞毒性活性。显示细胞毒性活性的化合物被进行了凋亡测定。两种化合物显示出了有前景的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/3269bca54581/molecules-15-00012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/cb9e25749286/molecules-15-00012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/c4f996cce7d8/molecules-15-00012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/7c41c214f1d5/molecules-15-00012-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/7751acc6f68f/molecules-15-00012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/dd6b15dcd1ce/molecules-15-00012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/3269bca54581/molecules-15-00012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/cb9e25749286/molecules-15-00012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/c4f996cce7d8/molecules-15-00012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/7c41c214f1d5/molecules-15-00012-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/7751acc6f68f/molecules-15-00012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/dd6b15dcd1ce/molecules-15-00012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b41/6256932/3269bca54581/molecules-15-00012-g004.jpg

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本文引用的文献

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