Márky I, Samuelsson B O, Mellander L, Karlberg J
Department of Pediatrics I, Gothenburg University, Sweden.
Med Pediatr Oncol. 1991;19(2):96-9. doi: 10.1002/mpo.2950190205.
Longitudinal growth was studied in children treated for non-Hodgkin's lymphoma (NHL). The aim of the study was to compare these children's growth velocity with findings in a previous study we performed on age-matched children with acute lymphoblastic leukemia (ALL) who received cranial irradiation. Nine children with NHL with an onset time of treatment between 4 and 9 years of age (mean 6.5 years) were studied with annual body measurements taken from the time of the diagnosis and thereafter annually during the following 4 years. None of the children received cranial irradiation. During the first treatment year a significantly low mean height velocity was observed (-1.4 standard deviation score [SDS]) for the NHL group. The consecutive two 1 year periods showed a normalization of the mean height velocity. For the group of children with ALL, there was a more prominent negative effect on height during the first 2 years of treatment than for the NHL group in the present study. After the cessation of therapy, the children with NHL showed a reduced catch-up growth compared with the children with ALL. The explanation offered is that cranial irradiation has a heavier impact on growth than chemotherapy during the first 2 years of treatment, but an intense chemotherapy during the maintenance period could have a considerable impact in blunting growth.
对接受非霍奇金淋巴瘤（NHL）治疗的儿童的纵向生长情况进行了研究。本研究的目的是将这些儿童的生长速度与我们之前对接受颅脑照射的年龄匹配的急性淋巴细胞白血病（ALL）儿童的研究结果进行比较。对9名治疗开始时间在4至9岁（平均6.5岁）之间的NHL儿童进行了研究，从诊断时起每年测量身体指标，并在接下来的4年中每年进行测量。所有儿童均未接受颅脑照射。在第一个治疗年，NHL组观察到平均身高增长速度显著较低（-1.4标准差评分[SDS]）。随后的两个1年期显示平均身高增长速度恢复正常。对于ALL儿童组，在治疗的前两年对身高的负面影响比本研究中的NHL组更为明显。治疗停止后，与ALL儿童相比，NHL儿童的追赶生长减少。对此的解释是，在治疗的前两年，颅脑照射对生长的影响比化疗更大，但维持期的强化化疗可能对生长抑制有相当大的影响。
