Thun-Hohenstein L, Frisch H, Schuster E
Department of Pediatrics, University of Zurich, Switzerland.
Horm Res. 1992;37(3):91-5. doi: 10.1159/000182289.
The effect of radio- and chemotherapy on auxological parameters was investigated in 30 children treated for acute lymphatic leukemia (ALL) or non-Hodgkins lymphoma (NHL). Growth velocity was decreased during the first year of treatment. Catch-up growth was insufficient during the following years. Thus, the whole group experienced a loss of height of 0.49 +/- 1.1 SD at 6.8 +/- 2.6 years after diagnosis. Height and growth velocity were not different between children who received 18 or 24 Gy cranial irradiation; however, growth velocity was significantly lower in children who were treated for more than 2 years or who had the more intensive chemotherapeutic protocol. Evaluation of the growth hormone (GH) response to pharmacological stimulation revealed reduced GH peaks in 47% of the patients, but there was no correlation of GH peak with growth or treatment parameters. In conclusion, the impairment of growth in children after treatment for ALL or NHL might be related to the intensity and duration of chemotherapy.
对30名接受急性淋巴细胞白血病（ALL）或非霍奇金淋巴瘤（NHL）治疗的儿童，研究了放疗和化疗对体格学参数的影响。在治疗的第一年生长速度下降。在随后几年中追赶生长不足。因此，整个研究组在诊断后6.8±2.6年时身高损失了0.49±1.1标准差。接受18 Gy或24 Gy颅脑照射的儿童之间身高和生长速度没有差异；然而，接受治疗超过2年或采用更强化疗方案的儿童生长速度显著更低。对生长激素（GH）对药物刺激的反应评估显示，47%的患者GH峰值降低，但GH峰值与生长或治疗参数之间没有相关性。总之，ALL或NHL治疗后儿童生长受损可能与化疗的强度和持续时间有关。
