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定义膀胱过度活动症治疗中的疗效。

Defining efficacy in the treatment of overactive bladder syndrome.

作者信息

Shah Sagar, Nitti Victor W

机构信息

Department of Urology, New York University School of Medicine New York, NY.

出版信息

Rev Urol. 2009 Fall;11(4):196-202.

PMID:20111632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2809987/
Abstract

Patients seek treatment for overactive bladder syndrome (OAB) due to poor quality of life, and perceived improvement in quality of life (QOL) from medical therapy is multifactorial. Many feel that efficacy/success of medical therapy for OAB should not be linked to improvements in 1 or 2 endpoints, but instead should be linked to patient expectation and QOL improvement. Ideally, once patient-centered goals are defined, outcomes should be correlated with relief of symptom(s), patient satisfaction, and goal attainment expectations as a result of treatment.

摘要

患者因生活质量差而寻求治疗膀胱过度活动症(OAB),而医学治疗带来的生活质量(QOL)改善是多因素的。许多人认为,OAB医学治疗的疗效/成功率不应与一两个终点指标的改善相关联,而应与患者期望和生活质量改善相关联。理想情况下,一旦确定了以患者为中心的目标,治疗结果应与症状缓解、患者满意度以及治疗后目标达成期望相关联。

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本文引用的文献

1
Patient-reported reasons for discontinuing overactive bladder medication.患者报告的停止治疗膀胱过度活动症的原因。
BJU Int. 2010 May;105(9):1276-82. doi: 10.1111/j.1464-410X.2009.09036.x. Epub 2009 Nov 12.
2
Extended-release trospium chloride improves quality of life in overactive bladder.盐酸托特罗定控释片改善膀胱过度活动症患者的生活质量。
Value Health. 2010 Mar-Apr;13(2):251-7. doi: 10.1111/j.1524-4733.2009.00652.x. Epub 2009 Oct 8.
3
The evolution of transdermal/topical overactive bladder therapy and its benefits over oral therapy.经皮/局部膀胱过度活动症治疗的进展及其相对于口服治疗的优势。
Rev Urol. 2009 Winter;11(1):1-6.
4
Effects of flexible-dose fesoterodine on overactive bladder symptoms and treatment satisfaction: an open-label study.灵活剂量非索罗定对膀胱过度活动症症状及治疗满意度的影响:一项开放标签研究。
Int J Clin Pract. 2009 Apr;63(4):560-7. doi: 10.1111/j.1742-1241.2009.02035.x.
5
Efficacy and safety of oxybutynin chloride topical gel for overactive bladder: a randomized, double-blind, placebo controlled, multicenter study.氯化奥昔布宁外用凝胶治疗膀胱过度活动症的疗效与安全性:一项随机、双盲、安慰剂对照、多中心研究。
J Urol. 2009 Apr;181(4):1764-72. doi: 10.1016/j.juro.2008.11.125. Epub 2009 Feb 23.
6
The effects of reformulation: improved therapeutic index.重新配方的效果:提高治疗指数。
Curr Urol Rep. 2008 Nov;9(6):465-71. doi: 10.1007/s11934-008-0080-6.
7
Darifenacin treatment for overactive bladder in patients who expressed dissatisfaction with prior extended-release antimuscarinic therapy.对于对先前的缓释抗毒蕈碱疗法表示不满的膀胱过度活动症患者,使用达非那新进行治疗。
Int J Clin Pract. 2008 Nov;62(11):1664-74. doi: 10.1111/j.1742-1241.2008.01893.x. Epub 2008 Sep 22.
8
Long-term benefits of darifenacin treatment for patient quality of life: results from a 2-year extension study.达非那新治疗对患者生活质量的长期益处:一项为期2年的延长期研究结果
Neurourol Urodyn. 2008;27(6):540-7. doi: 10.1002/nau.20620.
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Impact of fesoterodine on quality of life: pooled data from two randomized trials.非索罗定对生活质量的影响:两项随机试验的汇总数据
BJU Int. 2008 Jul;102(1):56-61. doi: 10.1111/j.1464-410X.2008.07710.x.
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Persistence, adherence, and switch rates among extended-release and immediate-release overactive bladder medications in a regional managed care plan.在一个地区性管理式医疗计划中,长效和速释型膀胱过度活动症药物的持续用药率、依从率及换药率。
J Manag Care Pharm. 2008 Apr;14(3):291-301. doi: 10.18553/jmcp.2008.14.3.291.