Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
J Oncol. 2010;2010:314326. doi: 10.1155/2010/314326. Epub 2010 Jan 13.
Epithelial ovarian cancer remains a major women's health problem due to its high lethality. Despite great efforts to develop effective prevention and early detection strategies, most patients are still diagnosed at advanced stages of disease. This pattern of late presentation has resulted in significant challenges in terms of designing effective therapies to achieve long-term cure. One potential promising strategy is the application of targeted therapeutics that exploit a myriad of critical pathways involved in tumorigenesis and metastasis. This review examines three of the most provocative targeted therapies with current or future applicability in epithelial ovarian cancer.
上皮性卵巢癌因其高致死率仍然是一个主要的妇女健康问题。尽管为开发有效的预防和早期检测策略做出了巨大努力,但大多数患者仍在疾病晚期被诊断出来。这种晚期出现的模式在设计有效的治疗方法以实现长期治愈方面带来了巨大的挑战。一种潜在的有前途的策略是应用靶向治疗,利用涉及肿瘤发生和转移的无数关键途径。这篇综述检查了目前或未来在上皮性卵巢癌中具有应用前景的三种最具争议性的靶向治疗方法。