Hafnia Unit of Biogerontology, Frederiksberg, Denmark.
Biogerontology. 2010 Aug;11(4):495-9. doi: 10.1007/s10522-010-9264-9. Epub 2010 Jan 29.
The data presented demonstrates a correlation of plasma cortisol levels and receptor sensitivity with mammalian longevity and replicative senescence; observations possibly related to the influence of cortisol on chaperone expression and cancer resistance. The molecular chaperones are essential structural and functional elements of the steroid hormone receptors, and serve to modify the sensitivity of the cortisol receptor. Cushing's syndrome illustrates the harmful effects of sustained high levels of cortisol; thus probably the circadian and stress-induced variations, as well as the hormone levels are important for the homeostatic effects of the steroid hormones in counteracting the age related decline of chaperone response and of possible importance for the evolution of mammalian longevity.
所呈现的数据表明，血浆皮质醇水平和受体敏感性与哺乳动物的寿命和复制性衰老相关；这些观察结果可能与皮质醇对伴侣蛋白表达和癌症抵抗力的影响有关。分子伴侣是甾体激素受体的必需结构和功能元件，可调节皮质醇受体的敏感性。库欣综合征说明了皮质醇持续高水平的有害影响；因此，皮质醇的昼夜和应激诱导变化以及激素水平可能对甾体激素的动态平衡效应很重要，有助于对抗与年龄相关的伴侣蛋白反应下降，并可能对哺乳动物寿命的进化具有重要意义。
