Fleischmann L, Pedrazzoli A
Arzneimittelforschung. 1977;27(6):1199-201.
The values of the diffusion constants at the different pH-values obtained using Stricker's apparatus, demonstrate that 2-propargyloxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 46-1) is characterized by a good absorption rate at gastric level and by a high absorption rate in the intestinal tract. The per cent of parsalmide bound to serum proteins, mainly to serum albumin, decreases with increasing concentration of parsalmide. Human serum binds about 55--70%, whereas bovine and equine serum bind about 40--60% of parsalmide at the different concentrations tested. The binding between parsalmide and serum proteins is a weak one: bound parsalmide is therefore set free very easily.
使用施特里克装置在不同pH值下获得的扩散常数表明，2-丙炔氧基-5-氨基-N-（正丁基）-苯甲酰胺（帕撒米特，My 46-1）的特点是在胃水平具有良好的吸收率，在肠道中具有高吸收率。与血清蛋白（主要是血清白蛋白）结合的帕撒米特百分比随帕撒米特浓度的增加而降低。在测试的不同浓度下，人血清结合约55%-70%的帕撒米特，而牛血清和马血清结合约40%-60%的帕撒米特。帕撒米特与血清蛋白之间的结合较弱：因此，结合的帕撒米特很容易被释放出来。
