Guo Hai-bin, Zhang Yu-hui, Zhang Cui-lian, Li Hang-sheng, Gu Bao-xia, Yin Bao-li, Song Xiao-bing, Xie Juan-ke
Institute of Reproductive Medicine, Henan Province Peoples Hospital, Zhengzhou, Henan 450003, China.
Zhonghua Nan Ke Xue. 2009 Oct;15(10):925-8.
To compare the outcomes of intracytoplasmic sperm injection (ICSI) with retrieved epididymal and testicular sperm for obstructive azoospermia and with ejaculated sperm for severe oligozoospermia and asthenospermia.
We retrospectively analyzed 431 ICSI cycles, which were divided according to sperm sources into Groups A (n=287 in patients with severe oligozoospermia or asthenospermia using ejaculated sperm), B (n=109 in obstructive azoospermia patients with sperm retrieved by percutaneous epididymal sperm aspiration, PESA) and C (n=35 in obstructive azoospermia patients with sperm retrieved by testicular sperm extraction, TESE). Comparisons were made among the three groups in the rates of embryo implantation, fertilization, pregnancy, cleavage, and miscarriage.
Group A showed statistically significant differences from Groups B and C in the rates of embryo implantation and pregnancy (18.46% vs. 25.23% and 28.76%, 31.23% vs. 42.16% and 39.39%, P < 0.05). But no significant differences were seen in the rates of fertilization, cleavage and miscarriage among the three groups (P > 0.05).
The rates of embryo implantation and clinical pregnancy are higher in patients with obstructive azoospermia than in those with severe oligozoospermia or asthenospermia after ICSI with ejaculated sperm.
比较卵胞浆内单精子注射（ICSI）使用附睾和睾丸获取精子治疗梗阻性无精子症以及使用射出精子治疗严重少精子症和弱精子症的结局。
我们回顾性分析了431个ICSI周期，根据精子来源将其分为A组（n = 287，严重少精子症或弱精子症患者使用射出精子）、B组（n = 109，梗阻性无精子症患者经皮附睾精子抽吸术获取精子）和C组（n = 35，梗阻性无精子症患者睾丸精子提取术获取精子）。比较三组之间的胚胎着床率、受精率、妊娠率、卵裂率和流产率。
A组与B组和C组相比，胚胎着床率和妊娠率有统计学显著差异（18.46% 对25.23% 和28.76%，31.23% 对42.16% 和39.39%，P < 0.05）。但三组之间的受精率、卵裂率和流产率无显著差异（P > 0.05）。
ICSI使用射出精子治疗时，梗阻性无精子症患者的胚胎着床率和临床妊娠率高于严重少精子症或弱精子症患者。
