Sendhilvadivu M
Department of Zoology, Auxillium College, Gandhi Nagar Vellore 632 006, India.
Indian J Exp Biol. 2009 Oct;47(10):839-42.
Male albino rats were sciatectomized and kept for 30 days to assess the induced oxidative damage due to disuse gastrocnemius muscle atrophy. An enhanced lipid peroxidation was recorded with elevated activity levels of conjugated diens, malondialdehyde and other thiobarbituric acid reactive substances in denervated muscle. The activity levels of antioxidant defense enzymes, viz. superoxide dismutase, catalase, glutathioneperoxidase (selenium, non-selenium), glutathione reductase, glutathione-s-transferase were depleted in the denervated muscle. The denervated muscle was subjected to a programme of in vivo electrical stimulations, revealed a depleted lipid peroxidation and increased activity levels of antioxidant defense enzymes. The results, suggest that the programme of in vivo electrical stimulation could prevent the oxidative damage in gastrocnemius muscle despite denervation.
将雄性白化病大鼠坐骨神经切断，并饲养30天，以评估因废用性腓肠肌萎缩引起的氧化损伤。在去神经支配的肌肉中，共轭二烯、丙二醛和其他硫代巴比妥酸反应性物质的活性水平升高，脂质过氧化增强。抗氧化防御酶，即超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶（含硒、不含硒）、谷胱甘肽还原酶、谷胱甘肽-S-转移酶的活性水平在去神经支配的肌肉中降低。对去神经支配的肌肉进行体内电刺激程序，结果显示脂质过氧化减少，抗氧化防御酶的活性水平增加。结果表明，尽管存在去神经支配，体内电刺激程序仍可预防腓肠肌的氧化损伤。
