Rathod R T, Misra D
German Remedies Division, Cadila Healthcare Limited, Mumbai 400018. [corrected]
J Indian Med Assoc. 2009 Aug;107(8):562-4.
Allergic rhinitis is the most common allergic disease worldwide and affects about 18% to 40% of the general population. Anti-allergic medicines (eg, some antihistamines) can cause adverse events such as somnolence and can have an additional negative impact on quality of life. Combining montelukast with levocetirizine gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by persistent allergic rhinitis. Montelukast sodium is alkaline, stable and levocetirizine dihydrochloride is acid stable, when we prepare a matrix tablet, both the drugs would be in contact and make it unstable during the shelf life of the formulation. Hence it is recommended to prepare bilayer tablet, as it improves and increases the stability of both the drugs in combination. Bilayer tablet of montelukast with levocetirizine is more stable with respect to stability studies, in comparison to matrix tablet.
变应性鼻炎是全球最常见的变应性疾病，影响约18%至40%的普通人群。抗过敏药物（如某些抗组胺药）可引起嗜睡等不良事件，并会对生活质量产生额外的负面影响。与单独使用任何一种药物相比，孟鲁司特与左西替利嗪联合使用具有额外的益处，对于因持续性变应性鼻炎而生活质量受损的患者可考虑使用。孟鲁司特钠呈碱性且稳定，而盐酸左西替利嗪呈酸稳定，当我们制备骨架片时，两种药物会接触并在制剂的保质期内使其不稳定。因此，建议制备双层片，因为它可提高并增强两种药物联合使用时的稳定性。与骨架片相比，孟鲁司特与左西替利嗪的双层片在稳定性研究方面更稳定。
