可扩展合成隐色烯-1.1.1 及其功能化。

Scalable synthesis of cryptophane-1.1.1 and its functionalization.

机构信息

CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.

出版信息

Org Lett. 2010 Mar 5;12(5):960-2. doi: 10.1021/ol902952h.

PMID:20112945

Abstract

Cryptophanes, cage molecules for which xenon exhibits a high affinity, are good candidates for xenon biosensing. Cryptophane-1.1.1 (1) exhibits the highest binding constant for xenon encapsulation in organic solution determined to date. This property suggests that the cryptophane-1.1.1 core (1) is optimal for sensing applications. A high-yielding scalable synthesis of compound 1 is reported as well as an easy way to functionalize it.

摘要

笼状分子 Cryptophanes 对氙气表现出高亲和力，是氙气生物传感的良好候选物。在有机溶液中，Cryptophane-1.1.1（1）对氙气的包合表现出迄今为止测定的最高结合常数。该性质表明 Cryptophane-1.1.1 核心（1）非常适合传感应用。本文报道了化合物 1 的高产可扩展合成方法，以及对其进行功能化的简便方法。