Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio 43205, USA.
Ren Fail. 2010 Jan;32(1):1-9. doi: 10.3109/08860220903288534.
The importance of cardiovascular disease in adults with chronic kidney disease is now well recognized. For children who develop chronic kidney disease, cardiovascular disease is also a leading cause of eventual morbidity and mortality. Although the clinical manifestations of cardiovascular disease may not be apparent until later, early subclinical findings can be observed even during childhood. This review updates the reader on the epidemiology of cardiovascular disease in pediatric chronic kidney disease, discusses risk factors and potential mechanisms of accelerated cardiovascular disease, reviews evidence of early manifestations of cardiovascular disease in pediatric chronic kidney disease, and briefly discusses prevention and treatment strategies.
心血管疾病在慢性肾脏病成人患者中的重要性已得到广泛认可。对于患有慢性肾脏病的儿童，心血管疾病也是导致最终发病率和死亡率的主要原因。尽管心血管疾病的临床表现可能要到以后才会显现，但即使在儿童期也可以观察到早期亚临床发现。本文综述了儿科慢性肾脏病患者心血管疾病的流行病学，讨论了加速心血管疾病的危险因素和潜在机制，回顾了儿科慢性肾脏病患者心血管疾病早期表现的证据，并简要讨论了预防和治疗策略。
