严重联合免疫缺陷患者的神经认知功能。

Neurocognitive function of patients with severe combined immunodeficiency.

机构信息

Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS # 62, Los Angeles, CA 90027, USA.

出版信息

Immunol Allergy Clin North Am. 2010 Feb;30(1):143-51. doi: 10.1016/j.iac.2009.10.003.

DOI:10.1016/j.iac.2009.10.003

PMID:20113891

Abstract

Hematopoietic stem cell transplantation (HSCT) has offered a curative approach for treating patients with severe combined immunodeficiency (SCID). However, HSCT may have long-term effects on some of these patients. This article reviews the literature regarding long-term neurocognitive function of patients who have received HSCT for SCID, including the effect of disease-specific characteristics, psychosocial factors, being a chronically ill child, and transplant-related factors.

摘要

造血干细胞移植（HSCT）为治疗严重联合免疫缺陷（SCID）患者提供了一种有治愈可能的方法。然而，HSCT 可能会对这些患者中的一些人产生长期影响。本文综述了有关接受 HSCT 治疗 SCID 的患者的长期神经认知功能的文献，包括疾病特异性特征、心理社会因素、作为慢性疾病儿童以及与移植相关的因素的影响。