Division, Blood/Marrow Transplantation and Immunology, Center for Cancer and Blood Disorders, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 10010, USA.
Hematol Oncol Clin North Am. 2010 Feb;24(1):109-27. doi: 10.1016/j.hoc.2009.11.010.
The past 25 years have seen an increase in our understanding of immunology and further expansion in the clinical use of immunotherapeutic modalities. How immunotherapy will be integrated with chemotherapy, radiation, and surgery remains to be established. Although there have been successes in the field of immunotherapy, they have been inconsistent, and it is hoped that increased understanding of the basic principles of immunology will improve the consistency of beneficial effects. In this article, we briefly provide a general overview of our current understanding of the immune system, with a focus on concepts in tumor immunology, followed by a discussion of how these concepts are being used in the clinic.
过去 25 年来，我们对免疫学的理解有所增加，免疫治疗模式的临床应用也进一步扩大。免疫疗法如何与化疗、放疗和手术相结合仍有待确定。尽管免疫疗法领域取得了一些成功，但这些成功并不一致，人们希望对免疫学基本原理的深入了解将提高有益效果的一致性。在本文中，我们简要概述了我们目前对免疫系统的理解，重点是肿瘤免疫学中的概念，然后讨论了这些概念如何在临床上得到应用。
