疟原虫血红素：疟疾的“内建”佐剂和 TLR9 激动剂。
Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist.
机构信息
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, 81675 München, Germany.
出版信息
Cell Host Microbe. 2010 Jan 21;7(1):5-6. doi: 10.1016/j.chom.2010.01.002.
PMID:20114022
Abstract
The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
摘要
全微生物疫苗中的“内建”佐剂可能引发保护性免疫。Coban 等人现在证明，疟原虫恶性疟原虫的粗血期提取物通过血红素解毒的副产物疟色素，驱动寄生虫特异性免疫反应，作为 TLR9 激动剂，因此作为“内建”佐剂。
Zotero 插件