Green A R, Salvaris E, Begley C G
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Oncogene. 1991 Mar;6(3):475-9.
The SCL gene encodes a member of the 'helix-loop-helix' family of DNA binding regulatory proteins. It is transcriptionally activated in some cases of T-cell acute lymphoblastic leukaemia by a reciprocal translocation involving the T cell receptor delta locus. In order to gain insight into the normal functions of SCL we have studied SCL mRNA levels in human and murine haemopoietic cell lines and normal tissues. We have observed high levels of SCL mRNA in all human and murine erythroid cell lines examined. Foetal and adult normal haemopoietic cell populations rich in erythroid precursors also expressed high levels of SCL mRNA. Our results suggest a previously unexpected role for SCL in the regulation of erythropoiesis.
SCL基因编码DNA结合调节蛋白的“螺旋-环-螺旋”家族成员。在某些T细胞急性淋巴细胞白血病病例中，它通过涉及T细胞受体δ基因座的相互易位而被转录激活。为了深入了解SCL的正常功能，我们研究了人和鼠造血细胞系及正常组织中SCL mRNA的水平。我们在所检测的所有人和鼠红系细胞系中均观察到高水平的SCL mRNA。富含红系前体细胞的胎儿和成人正常造血细胞群体也表达高水平的SCL mRNA。我们的结果提示SCL在红细胞生成调节中具有先前未预料到的作用。
